Original Articles: 2012 Vol: 4 Issue: 8
Synthesis, characterization and evaluation of analgesic activity of some 5-nitro benzimidazole derivatives
In literature benzimidazole derivatives are reported to possess variety of pharmacological activities of which analgesic activity is one of the important. Moreover benzimidazole derivatives have found their clinical application as analgesic agent. Orthophenylenediamine and 4-choro orthophenylenediamine were condensed with three varieties of substituted benzoic acid to get six benzimidazole derivatives, of which nitration were carried out to obtain their corresponding 5-nitro derivatives. The synthesized compounds were characterized by IR and 1H-NMR spectroscopy. Determination of melting point, Rf value and solubility profile for all compounds were carried out. The synthesized compounds were evaluated for their analgesic activity by the tail flick method in mice. Maximum of the compounds exerted interesting profile of analgesic activity the dose 200 mg/kg b.w.