A new spirochromanones based on N-[1-(6-bromo-4-oxo -3, 4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1' -yl)-3- methyl-1-oxobutan-2-yl] benzenesulfonamides were sy nthesized by series of reactions such as cyclizatio n, deprotation, coupling and condensation. Newly synth esized compounds were characterized by spectroscopi c techniques like NMR, IR, Mass spectrometry and elem ental analysis. The compounds were tested to emphas ize their activity against the fungi and pathogenic strains o f bacteria. The compounds bearing fluoro, cyano and difluoromethoxy groups at para position showed comp etitive antifungal activity, while the compounds ca rrying either halogen or methyl substituent at ortho posit ion showed significant antibacterial activity.