Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 1

Synthesis, characterization and biological activities of some new hypophosphorousadducts of acidhydrazones derived from 2-[(N-acetyl) 2, 3-dichloroanilido] acetohydrazide


A new series of hypophosphorousadducts of acidhydrazones have been synthesized by the reaction of 2-[N- (acetyl) 2, 3-dichloroanilido acetohydrazide with various Carbonyl Compounds in 39 to 67% yield. Newly synthesized compounds have been tested for their antibacterial activity against gram positive bacteria S.albus, S.aureus and gram negative bacteria E.coli and Pseudomonas piosineus. The compound (1, 2, 3, 5, 7, 10, 12, 15) shown significant activities and compound (4, 6, 9, 13, 14, 17) have shown moderate activity. The same compounds were tested for their anti-fungal activity against Candida albicans, Aspergillus niger and Alternaria alternata at concentration of 30 mg/ml using Savored dextrose agar media. The compound (3, 5, 7, 9, 11, 14) shown significant activities and compound (2, 4, 6, 12, 13, 16) have shown moderate activity against Candida albicans and Aspergillus niger. All the other compounds did not show significant activity against the fungi at the concentration used.

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