The 1- (3-Methyl-1-Phenyl-5-thioxo-4,5-dihydro-1H-Pyrazole-4-yl)-Ethanone condensation with various substituted aldehydes was yielding various Chalcone. Further this Chalcone conversed into pyrazole by condensation with various synthesized Chalcone with isoniazide. In the present research article a new series of pyrazole derivatives have been synthesized. The structure of newly synthesized compounds is characterized on the basis of IR, 1 H NMR, Mass spectroscopes and elemental analysis. The newly synthesized compounds were studied for biocedal activity.