Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 1

Synthesis, characterization and bioactivities of Ni(II) and Co(II) complexes of benzyloxybenzaldehydethiosemicarbazone

Abstract

Ni(II) and Co(II) complexes of benzyloxybenzaldehyd ethiosemicarbazone(L) were prepared and characterized by their physical, spectral and analy tical data. The newly synthesized metal complexes have a composition of [M(L) 2 X 2 ], where M= Co(II) or Ni(II) and X= Cl. The electronic spectral studies show an octahedral geom etry around Ni(II) and Co(II) complexes. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination with the central metal ion. In order to evaluate th e biological activity of the ligand and its metal , complexes have been screened for their antibacteria l and antifungal activity against bacterial species like – B.subtilis and S.aureus (Gram-positive bacteria) and E. coli, P. aeruginosa and P. vulgaris (Gram-negative bacteria) and also fungal species like- Microsporumgypseum, Teloschistes villous, Aspergillus fumigates and Can dida albicans . The results of antimicrobial studies clearly show that the process of chelation dominantly affects the overall biological behaviour of the compounds and they are potent agai nst bacterial and fungal strains. The free ligand and its corresponding metal complexes were s creened for antioxidant properties by radical scavenging methods such as 1,1-diphenyl -2-picryl h ydrazyl (DPPH) and lipid peroxidation. They exhibited potent invitro - antioxidant activit y dose dependently.