Metal complexes of ciprofloxacin with Co(II), Ni(II) and Cu(II) chloride salts were prepared using a literature procedure. The complexes were characterized by conductivity measurement, Uv/Visible and FTIR spectroscopy. Based on the IR, Uv/visible spectroscopies and microanalysis data, the compounds formed by the ciprofloxacin have their formula proposed as [M(Cp)2Cl2).6H2O]- 1 where M= Ni and H3Cp[MCl2(H2O)2]- 2 where M= Co or Cu. The ligand and the complexes showed varying degrees of solubilities in polar and non-polar solvents. Conductivity measurement showed that all the complexes were non electrolytes (14.4 – 49.9 S cm2 mol-1). IR and microanalysis data revealed that ciprofloxacin acted as a bidentate ligand which coordinated to the metal ions through the ring carbonyl oxygen and one of the O atom of the carboxylate group. The complexes were also tested for their antimicrobial activity against eight different bacterial strains such as Esherichia coli, Klebsialla pneumoniae, Salmonella typhi, Pseudomonas aeruginosa, Streptococcus pyogenes, Staphylococcus aureus, Bacillus subtilis and Corynebacterium pneumoniae at 20mg/ml, 15mg/ml and 10mg/ml concentration levels using agar disc diffusion method. The results showed that all the ciprofloxacin complexes were highly efficacious against all the tested strains except Staphylococcus aureus.