A copolymer was synthesized from resorcinol and melamine using formaldehyde as a cross linking agent at 126 0C in 2M HCl medium. The resin was characterized by elemental analysis, FTIR and NMR spectra. The RMF resin was tested for its inhibitory action against pathogenic bacteria and fungi. The resin show potent inhibitory action against bacteria such as Escherichia coli, Klebseilla, Staphylococcus aureus and Pseudomonas aeruginosa and fungi viz. Aspergillus flavus, Aspergillus niger, Pencillium species, Candida albicans, Cryptococcus neoformans and Mucor species. The copolymer resin is soluble in DMF, DMSO, THF, conc. H2SO4.