A new series of thiazole Schiff base ligand was derived from the condensation of thiazole and 2-hydroxy-5-chloro- 3-nitro acetophenone. The Schiff bases behaved as charge bidentade ligand. The ligand was characterized by elemental analysis and spectral methods. The coordinating ability of the ligand is investigated by preparing its metal complexes with Cr(III), Mn(III), Fe(III), VO(IV), Zr(IV) and UO2(VI) have been prepared and characterized by elemental analysis, conductance measurements, molecular weight determinations and spectral studies. The synthesized products are coloured solids, soluble in DMF, DMSO and THF. The Schiff base and their metal complexes have been evaluated for their antibacterial activities