Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2017 Vol: 9 Issue: 4

Synthesis, Characterization and Antifungal Activity of 3-Substituted Triazipino [3,4-b] [1,3] Benzothiazole


A simple and efficient method have been used for the synthesis of 3-Substituted derivatives of 4-Cyano-5-imino-3-methylthio-9-nitro-2H-1,2,4-triazipino [3,4-b] [1,3] benzothiazole have been prepared through one Step Multicomponent reaction by heating a mixture of 2-hydrazino-6-nitro benzothiazole (I) and bis methylthio methylene malononitrile (II) independently with aromatic amines / phenols / heterylamines / compounds containing active methylene group respectively in the presence of dimethyl formamide and catalytic amount of anhydrous potassium carbonate. All these newly synthesized compounds were screened for antifungal activity.

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