Cinchonic acids are the useful synthons for the preparation of quinoline derivatives. They were prepared by employing Pfitzinger reaction starting from isatins and 2-acetylfuran. 3- Aryloxymethyl-4-amino-5-mercapto-1,2,4-triazoles on reacting with cinchonic acids in the presence of phosphorus oxychloride yielded 2-(2-furyl)-4-(3-aryloxymethyl-1,2,4-triazolo[3,4- b]-1,3,4-thiadiazol-6-yl)quinolines. The structures of these compounds were confirmed on the basis of elemental analysis and spectral data. These compounds were screened for their antibacterial activities against gram-positive and gram-negative bacteria.