Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 5

Synthesis, characterization and antibacterial activity studies of some triazolothiadiazolylquinolines


Cinchonic acids are the useful synthons for the preparation of quinoline derivatives. They were prepared by employing Pfitzinger reaction starting from isatins and 2-acetylfuran. 3- Aryloxymethyl-4-amino-5-mercapto-1,2,4-triazoles on reacting with cinchonic acids in the presence of phosphorus oxychloride yielded 2-(2-furyl)-4-(3-aryloxymethyl-1,2,4-triazolo[3,4- b]-1,3,4-thiadiazol-6-yl)quinolines. The structures of these compounds were confirmed on the basis of elemental analysis and spectral data. These compounds were screened for their antibacterial activities against gram-positive and gram-negative bacteria.

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