New mixed ligand complexes of the type [M(Fu)2A], where M is Ni (II), FU is furfural urea and A is either dimethylsulphoxide (DMSO), trimethylamine (TEA) or aniline were synthesized characterized by metal analysis, solubility test, melting/decomposition point, conductivity measurement, IR and UV/VIS spectroscopy. The mixed ligand complexes were also tested for their antimicrobial activity against Escherichia coli, Staphlococcus aureus and Salmonella paratyphi. There was evidence of coordination between the metal and the ligands and the electronic spectra suggested an octahedral geometry. All the complexes recorded appreciable activity against all the test organisms.