A series of novel substituted benzimidazole derivatives by the condensation of different diamines with anthranilicacid were synthesized. The subsequent reactions of the benzimidazole derivatives were reacted with different aromatic acid chlorides to get tetrazole moieties. These compounds were screened for their potential anti-cancer, anti-diabetic, anti-tumor and anti- asthmatic properties, which exhibited some authentic results towards testing organism invitro and invivo studies.