Original Articles: 2009 Vol: 1 Issue: 1
Synthesis, anti-microbial properties of 3-(3Ã?¢Ã?â?¬Ã?â?¢-Chloro-4Ã?¢Ã?â?¬Ã?â?¢-nitrophenyl)-2- (substituted phenoxy)-3,4-dihydro-2H-1,3,2 Ã?ŽÃ?»5Ã?¢Ã?â?¬Ã?â??benzoxaphosphinin-2-ones
Abstract
2-[(3'-chloro-4'-nitro phenylamino) methyl]phenol 1 underwent facile condensation with various phosphorus dichlorides 2a-j in the presence of TEA in dry THF at 60-65 and afforded corresponding 1,3,2 λ5 –benzoxaphosphinin-2-one derivatives 3a-j. Their chemical structures were characterized using IR, 1H, 13C, 31P NMR and mass spectral studies. All the above compounds were screened for anti-microbial activity and their bioassay showed them to possess significant antimicrobial activity