The novel resins were synthesized by polycondensation reaction of substituted resorcinol, formaldehyde and biuret using HCl as catalyst. The structures of these resins were studied using various characterization techniques such as FTIR, 1H-NMR spectral data. The antibacterial screening against Escherichia coli, Proteus vulgaris, Bacillus substillis, Staphylococcus and antifungal activity against Drecherahalodes, Fusarium oxysporium of these resins were also evaluated. It is found that parachlorophenyl substituted based copolymer resin is more active than other resins. Similarly, acid catalyzed terpolymer resins were found to be more potent than base catalysed resins.