Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 5

Synthesis, anticonvulsant activity & spectral characterization of some novel thiazolidinone derivatives


A series of substituted 5-ethylidene-2-(phenylimino) thiazolidin-4-ones were prepared and evaluate for their potential anticonvulsant activity by determining their ability to provide protection against convulsions induced by electroconvulsometer. The synthetic scheme involves phenylthiourea (I) as a starting material. Phenylthiourea on reaction with ethylchloroacetate in presence of ethanol (95%) and fused sodium acetate gives 2-(phenylimino) thiazolidin-4-one (II), 2-(phenylimino) thiazolidin-4-one on further reaction with substituted benzaldehyde gives substituted 5-ethylidene-2-(phenylimino) thiazolidin-4-one (III-VII). Synthesized compounds were authenticated on the basis of elemental analysis, IR and 1H NMR and Mass spectral analysis.