A new series of Anti bacterial and Antifungal agent s with 2-(5-amino-1, 3, 4-thiadiazol-2-yl) phenol as the central scaffold unit has been synthe sized. The newly synthesized compounds were characterized by IR and 1 HNMR spectral methods. The compounds were screened for antibacterial activity against pathogenic microbes Bacillus subtilus, Staphylococcus aureus, E.coli, in comparison with the reference drug Ampic illin, Ciprofloxacin and Doxycycline and antifungal activity against Candida albicans and co mparable to that of Fluconazole as a reference drug and in this investigation the signif icant level of activity was illustrated.