Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2013 Vol: 5 Issue: 4

Synthesis and pharmacological screening of derivatives of benzimidazole linked with quinoline and tetrazole

Abstract

Benzimidazolyl acetamide synthesised by the reaction of acetamide group containing acid with the ortho phenylene diamine in presence of polyphosphoric acid which on treatment with Vilsmeier–Haack reagent (DMF+ POCl3) gave the fused pyridine ring by cyclization, which gave compound 2-chloroquinoline 3-carbaldehyde. Further treatment with sodium azide gave quinoline ring fused with tetrazole. These compounds were containing the free aldehyde group in their structure which form Schiff base on treatment with the different substituted aniline. Elemental analysis, IR, 1H NMR, 13C NMR, and Mass spectral data were used to elucidate the structures of all newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds were investigated against Grampositive B. subtillus, S. aureus Gram-negative, K. pneumoniae, P. Aerugenosa and fungi Candida albicans, in comparison with standard drugs. Some of the tested compounds showed significant antimicrobial activity.