Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 5

Synthesis and microbial activity of 3-[4-Benzylidene-5-oxo-2-phenyl- 4,5-dihydro-imidazol-1-yl]-2-substituted-quinazolin-4(3H)-one and their derivatives

Abstract

Quinazolin-4(3H)-one based bis-azaheterocycles containing five or six membered heterocyclic ring at N-3 are medicinally important and majority of them are drug leads. Azlactones are also good pharmacophores and posses varied drug activity. Therefore a series of new compounds were prepared by condensation of 3-amino-2-substituted- 4(3H)-quinazolinones with different substituted azlactones in glacial acetic acid. The structures of synthesized compounds were confirmed on the basis of IR, NMR and mass spectral data. The compounds are screened for antibacterial activity.

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