Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 6

Synthesis and Fluorescence study of Novel Schiff Bases of Isoniazide


Isoniazide can be synthesized by the known literature method. Nicotin-4-carboxylic acid (1) was converted into methyl ester by using methanol in presence of catalytic amount of sulphuric acid. The methyl nicotin-4-carboxylate (2) is converted into isoniazide (3) by the condensation with hydrazine hydrate in DMF. The isoniazide is then condensed with various aldehydes (4a-d) in absolute alcohol in presence of catalytic amount of acetic acid and final product N[(1E)- alkylidene]pyridine-4-carbohydrazide (5a-d) is subjected for further fluorescence study.