The synthesis and biological evaluation of some novel angular furocoumarins was aimed at creating a new molecular frame work. Considering the side effect profile of linear furocoumarins, six new and unexplored angular furocoumarins i.e. 4-methyl 9-(substituted phenyl)-2H-furo[2,3-h]chromen-2-ones have been synthesized by reacting different para substituted acyl bromides with 4-methyl-7-hydroxy coumarin followed by cyclization in acidic medium. All these compounds were characterized by physical and spectral data. These compounds were screened for free radical scavenging activity by DPPH method and preliminary cytotoxic activity by using Ehrlich Ascites Carcinoma cells and Tryptan blue dye exclusion method. Among the compounds tested for radical scavenging and cytotoxic studies, 4b and 4c showed appreciable results when compared with the standard drugs ascorbic acid and 5- fluorouracil respectively.