A series of 5-(1-benzoylamino-2-(substitutedphenyl)vinyl)-2-amino-1,3,4-oxadiazoles derivatives 3(a-n) were synthesized by warming α-benzamido-cinnamhydrazides 2(a-n) and cyanogen bromide in ethanol. α-Benzamidocinnamhydrazides 2(a-n) were obtained by stirring 4-benzylidine-2-phenyloxazole-5-ones 1(a-n) with a 90 % hydrazine hydrate in ethanol. The chemical structures of title compounds were established by IR, 1H NMR. All the compounds were screened for antimicrobial and antioxidant activities .Among the series of the compounds i.e., 4- methoxy derivative (3g) showed significant antibacterial activity. Bromo vanillinyl derivative (3k) showed good nitric oxide scavenging activity. 4-dimethylamino derivative (3f) showed significant activity in reduction of DPPH.