Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2010 Vol: 2 Issue: 1

Synthesis and evaluation of some new substituted 1,4-dihydro pyridine derivatives and their anticonvulsant activity

Abstract

A series of substituted 1, 4-Dihydropyridine deriva tives were synthesized and the structures of these compounds were established on the basis of sp ectral and elemental analysis. All the compounds were evaluated for anti convulsant activi ty by Maximal Electroshock Induced convulsions in Rats, PTZ induced convulsions in Rat s, and Strychnine induced Convulsions in Rats methods. Compounds A 1 ,A 2 ,A 3 ,A 4 ,B 1 ,B 2 ,B 3 ,B 4 have been found to exhibit anti-convulsant activity.