Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 4

Synthesis and evaluation of dibenzo- 18 -crown -6 ether containing hydrazone derivative as antibacterial drug derivatives


New derivatives of the macrocyclic polyether dibenzo-18-crown-6 that contain hydrazone groupings in the aromatic rings were synthesized. The biological activity of the polyether ring and the hydrazone groupings was studied. The strategy employed for the synthesis of new macromolecules containing hydrazone moiety involved formylation of dibenzo -18-crown –6 1 to yield 4, 4'- diformyl derivative of dibenzo-18-crown- 6 2 which was further reacted with different substituted hydrazides to give corresponding hydazones 3. The structures of synthesized compounds have been characterized on the basis of spectroscopic data

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