In the present article synthesis and evaluation for antibacterial activity of a new series of (5-aryl-1,3,4-oxadiazol-2-yl) (pyridin-2-yl) methanol derivatives were described. The compounds were characterized by IR, NMR, and mass spectroscopy. All the synthesized compounds were screened for their antimicrobial activity against Staphylococcus epidermidis ATCC14990, Bacillus cereusPTCC1050, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922. The broth macrodilution and agar welldiffusion methods were used for determination of inhibition zoom(IZ) and minimum inhibitory concentration (MIC) during preliminary evaluation of antimicrobial activity. All of the synthesized compounds exhibited promising antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis.