Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2015 Vol: 7 Issue: 8

Synthesis and evaluation of 2-benzyl-3-hydroxybutanoic acid as inhibitor for carboxypeptidase A

Abstract

2-Benzyl-3-hydroxybutanoic acid(1) was prepared starting with acetoacitic ester following benzylation, reduction using sodium dithionite and hydrolysis under alkaline condition. The inhibitory kinetic evaluation showed that 1(Ki =107mM) is potent than 2-benzyl-3-hydroxypropanoic acid(Ki =610mM) as inhibitor for carboxypeptidase A, suggesting that introducing of a methyl group at the b-position of a inhibitor with weak zinc ligating moiety such as hydroxyl group to improve potency of inhibitor to CPA is possible.