The synthesis and characterization of some novel Pyrimidine derivatives have been presented. Acylation of resorcinol followed by nuclear prenylation with isoprene gives Chroman. Chroman on treatment with p-substituted benzaldehydes affords substituted chalcones. Pyrimidines have been prepared from chalcones by condensing with Guanidine hydrochloride in alkali medium. The structure of Pyrimidines has been characterized by spectral analysis.