Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2016 Vol: 8 Issue: 2

Synthesis and characterization of some novel isoxazolyl-1,3-thiazolidin-4-ones


A series of novel 1,3-thiazolidin-4-ones(2a-h) have been synthesiszed from isoxazolyl hydrazide-hydrazone derivatives(1a-h).These hydrazide-hydrazone derivatives undergoes cyclocondensation with mercaptoacetic acid in dioxane in the presence of anhydrous zinc chloride give title compounds in good yields(Table-I). Structure of all the synthesized compounds have been established on the basis of IR, 1HNMR and Mass spectral data.