Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 6

Synthesis and characterization of potential impurities in key intermediates of Carvedilol: a b-adrenergic receptor


Carvedilol is prepared by different synthetic approaches. One of the approach is the condensation of 4-(2, 3-epoxyprpoxy) carbazole with 2-(2-methoxyphenoxy) ethyl amine in monoglyme solvent. In this publication, impurities and their origin of formation during the synthesis of 4-(2, 3-epoxypropoxy) carbazole and 2-(2-methoxyphenoxy) ethyl amine is discussed. These impurities are synthesized and well characterized by spectral analysis.