Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2013 Vol: 5 Issue: 7

Synthesis and characterization of new quinazolineÃ?¢Ã?â?¬Ã?â??4(3H)-one Schiff bases

Abstract

In this work ,2-chloromethyle-4H-3,1-benzoxazine-4-one (2) has been synthesized via reaction of N-chloroacetyl anthranilic acid (1) and sulfuric acid while treatment of the compound (2) with morpholine gave compound (3). Compound (4) synthesized from compound (3) via reaction with hydrazine hydrate. More ever the reaction of compound (4) with different aldehydes gave the newly Schiff bases (5- 8). All compounds were confirmed by their melting point, FTIR, and UV-Vis spectra.