Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2017 Vol: 9 Issue: 4

Synthesis and Characterization of Dihydro-1H-Benzimidazole-8-Carboxylic Acids as a Potential Antimicrobial Agents


The structure activity relationships of 1H-benzimidazole-8-carboxylic acids (9a-9f), 1H-benzimidazole-8-carboxylates (8a-8f) are described. Characteristic compounds showed improved demanding activity over a previously recognized 2-aminobenzimidazole series. In the lead optimization process and structure–activity relationship (SAR) of separate inhibitors based on modification of the lead molecule (E)-1,6-dimethyl-9-oxo-2-styryl-6,9-dihydro-1H-imidazo[4,5-f]quinoline-8-carboxylic acids, identified from a high-throughput-screen. Noticeably, 4-chlorobenzyl, 4-fluorobenzyl benzimidazole derivatives 9c, 9e gave remarkable antimicrobial activities against saccharomyces cerevisiae, MRSA and bacillus proteus with MIC values of 1, 2 and 4 μg/mL, respectively. Experimental research revealed that compound 5c could effectively intercalate into calf thymus DNA to form compound 5c DNA complex which might block DNA replication and thus exert antimicrobial activities.

slot gacor 2023 slot deposit 5000 karangan bunga cilacap link slot gacor slot deposit dana karangan bunga cilacap karangan bunga mojokerto toko bunga cilacap karangan bunga purwokerto
mesin slot online slot online lapak pusat