Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 4

Synthesis and Characterization of bromo-nitro Chalcones and Isoxazolines


In the present study we have designed a synthesis of different substituted bromo-nitro-Chalcones (I a-d) by Claisen- Schmidt condensation of 2-hydroxy-3-bromo-4-nitro-5-methyl acetophenone with substituted aromatic aldehydes in ethanol using 40% KOH. By using these Chalcones, four different 3, 5-diaryl-Δ2- isoxazolines (II a-d) were synthesized with hydroxylamine hydrochloride in pyridine containing few drops of piperidine. The synthesized compounds were characterized by IR and 1H NMR spectral analysis.