Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2020 Vol: 12 Issue: 9

Synthesis and Characterization of Biologically Active Metal Complexes for Tenoxicam

Abstract

Biologically active [Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II)] complexes of tenoxicam were prepared and characterized using IR, UV-Vis, ESR, magnetic susceptibility, thermal analysis (TGA, DTA and DSC). IR data pointed that all complexes were suggested that tenoxicam coordinates to the metal ions as a bidentate ligand bound to metal through (C=N) nitrogen of pyridine ring, carbonyl oxygen of (C=O) and oxygen atom of OH group with stochiometries 1:2 (M:L). Electronic absorption spectra gathered with the magnetic moment values proved that all tenoxicam complexes have octahedral geometry. The calculated room temperature powdered ESR data of copper tenoxicam complex with the formula [Cu(tenoxicam)2Cl(H2O)], showed isotropic spectra. Thermal analyses (TGA and DTA) of ligands and their metal complexes were carried out to distinguish between the coordinate and hydrate solvents and to estimate the stability ranges, peak temperatures. The thermodynamic parameters, such as activation energy (ΔE*), enthalpy of activation (ΔH*), entropy of activation (ΔS*) and Gibbs free energy (ΔG*)are calculated and discussed. Antimicrobial activities were screened for some metal complexes of tenoxicam.