The target compound2-(arylamino)-4-(4-fluorophenyl/4-bromophenyl/isobutyl)-1,6-dihydro-1-methyl-6-oxopyri - midine -5-carbonitrilehave been synthesized by the condensation of 4-(4-fluorophenyl/4-bromophenyl/ isobutyl)-1,6- dihydro-1-methyl-2-(methylthio)-6-oxopyrimidine-5-carbonitrile with different aromatic amines using ethanol as solvent. Here three different aldehyde used in synthesis of 4-(4-fluorophenyl/4-bromophenyl/isobutyl)-1,6-dihydro- 1-methyl-2-(methylthio)-6-oxopyrimidine-5-carbonitrile.The obtained products were characterized by1H-NMR, Mass and IR Spectra and screened for their antibiotic activity against different gram positive and gram negative bacterial strain.