Original Articles: 2010 Vol: 2 Issue: 4
Synthesis and biological studies of unsymmetrical mannopyranosyl thiocarbamides
Synthesis of unsymmetrical N,N’-disubstituted Mannopyranosyl thiocarbamides by the interaction of N-tetra-O-acetyl-b-D-Mannopyranosyl isothiocyanate and free amines in ethanol. The polar solvent which increases the rate of reaction which was monitored by TLC while, the yield measured after completion of reaction with column chromatography. These compounds were screened for their antibacterial and antifungal activity against E. coli, S. aureus, P. vulgaris, Pseudomonas, Bacillus, S. typhi, A. niger and Fusarium.The identities of these newly synthesized compounds were established on the basis of elemental analysis UV, IR, 1H NMR, 13C NMR & Mass spectral studies.