The synthesis of two series of pyrazolo [3, 4-c]pyrazoles linked to pyridine (3a-d) and pyrrole (5a-d) is achieved by reaction of Chalcones of pyrazolone (3) and (5) with hydrazine hydrate, Thiosemicarbazide, semicarbazide and phenyl hydrazine in the presence of NaOH /EtOH or AcONa/AcOH. Chalcones (3) and (5) required for the synthesis are prepared by the condensation reaction of 5-methyl-2,4-dihydro-3H-pyrazol-3-one (1) with hetero Aromatic aldehydes (2) and (4). Compound 1 intern is prepared by the cyclization reaction between ethylacetoacetate and hydrazine hydrate in absolute alcohol. Structures of the synthesized compounds have been elucidated by means of IR, 1H NMR and mass spectral data. Biological screening of all compounds is reported.