A new series of Isoxazole and Benzodizepine derivatives were synthesized from chalcones and evaluated for their Antimicrobial activities. First Chalcones were prepared by treatment of Furan-2-Carbaldehyde with different acetophenones by Claisen-Schimidt Condensation. Various Isoxazole derivatives were prepared by reaction of Chalcone with Hydroxylamine Hydrochloride and Sodium Acetate in ethanol and Benzodizepine derivatives were prepared by reaction of Chalcone in ethanol with o-phenylenediamine in presence of piperidine. The structures of the newly synthesized Isoxazole and Benzodiazepine derivatives have been established on the basis of their spectral data. The synthesized selected compounds were evaluated for their antimicrobial activities