Various Chromene -2- one derivatives (1a-1f) were synthesized and evaluated for antipsychotic activity. All the synthesized compounds showed antipsychotic activity with muscle relaxant property. The compound 1d, N-(Fluoro benzothiazol-2-yl)-(4-Methyl-2-oxo-chromene-7-yloxy) acetamide has been found to have significant atypical behaviour.