Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2018 Vol: 10 Issue: 10

Synthesis and Biological Evaluation of Coumarin Derivatives as Antiproliferative Agents


The present research work involves the synthesis of a total of ten coumarin derivatives and their preliminary in vitro biological evaluation as anticancer agents. The newly synthesized compounds were characterized on the basis of various spectral analytical techniques like IR and 1H-NMR. In vitro testing was done using SRB assay protocol, each derivative was tested at 4 dose levels i.e. 10 μg/ml, 20 μg/ml, 40 μg/ml, 80 μg/ml. All the selected synthesized compounds were found to possess good to moderate anticancer activity. The order for the % control growth inhibition of SK-OV-3 cell line at 80 μg/ml was found to be 6j>6i>6d>6c>6e>6b>6a>6g.