Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2014 Vol: 6 Issue: 6

Synthesis and biological activity of some new thiazole based thiazolidinones


The basic compound 5-methyl-N-[(1-substituted phenyl) methylene] – 1,3-thiazol-2-amine [A 1-10] have been synthesized by reaction of 5-methyl amino thiazole and aromatic aldehyde in presence of toluene and further react with thioglycolic acid gives 3-(5-Subtituted 1,3-thiazol-2-yl)-2- (Substitued phenyl)-1, 3-thiazolidin-4-ones [B 1-10]. The structure of the final product is confirmed by IR, and 1H NMR spectral data. All the synthesized compounds were evaluated for their antibacterial activity to gram-positive and gram-negative bacteria. All the synthesized compounds have exhibited selective and effective active against gram-positive and gram-negative bacteria. Antibacterial activities of the synthesized compounds have been compared with standard drugs

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