Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 1

Synthesis and biological activity of 8-chloro-[1,2,4]triazolo [4,3-a]quinoxalines

Abstract

8-Chloro-1-substituted-[1,2,4]triazolo[4,3-a]quinox aline s 6 underwent facile condensation with various hydrocarbon derivatives in the presence of TEBAC in acetonitrile was refluxed and afforded corresponding 8-chloro-1,4-substituted-[1, 2,4]triazolo[4,3-a]quinoxaline derivatives 7a- j. Their chemical structures were characterized using IR, H 1 NMR and Mass spectral studies. All the above compounds were screened for anti-microbia l activity, anti-oxidant activity and their bioassay showed them to possess significant antimic robial activity and anti-oxidant activity.