4-Aminopyrimidine-5-carbonitrile (1) underwent faci le condensation with various aromatic acid derivatives in the presence of 1-[3-(dimethylamino) propyl]-3-ethylcarbodiimidehydrochloride (EDC.HCl) and small catalytic amount of TEA afforde d corresponding substituted-N-(5- cyanopyrimidin-4-yl)benzamide derivatives 3a-j. The y were characterized by IR, 1 H, NMR and Mass spectral data. All the compounds were screened for anti-microbial, anti-oxidant activities.