Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2015 Vol: 7 Issue: 1

Synthesis and antitumor activity in vitro of glioperazine C and its derivatives

Abstract

Glioperazine C, a naturally occurring diketopiperazine, together with its thirteen derivatives, were synthesized in 35-47% overall yields. The first total synthesis of glioperazine C was achieved by intermolecular condensation and intramolecular cyclization. Their structures were characterized on the basis of 1H, 13C NMR, and those compounds were evaluated for their anticancer activities against K562, HT-29 and HepG2 cell lines. Results showed that glioperazine C containing D-Trp and D-Thr demonstrated potent anticancer activity against HepG2 cell line (IC50=6.51μM).