Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2015 Vol: 7 Issue: 1

Synthesis and antimicrobial studies of fused heterocycles â??pyrimidobenzothiazolesâ??

Abstract

In the present work 2H-Pyrimido[2,1-b]benzothiazole-2-ones were synthesized by reacting 2-aminobenzothiazoles with alkynoic acid in butanol and 4H-Pyrimido[2,1-b]benzothiazole-4-ones were synthesized by the reaction of 2- aminobenzothiazoles with ethylacetoacetate in presence of polyphosphoric acid. The structures of synthesized compound were confirmed by IR, H1NMR & mass spectrum analysis. Synthesized compounds shown biological activity against E. coli and B. Subtilis and anti-fungal activity against A. fumigates.