Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 1

Synthesis and antimicrobial studies of fused heterocycles â??pyrimidobenzothiazolesâ??


In the present work 2H-Pyrimido[2,1-b]benzothiazole-2-ones were synthesized by reacting 2-aminobenzothiazoles with alkynoic acid in butanol and 4H-Pyrimido[2,1-b]benzothiazole-4-ones were synthesized by the reaction of 2- aminobenzothiazoles with ethylacetoacetate in presence of polyphosphoric acid. The structures of synthesized compound were confirmed by IR, H1NMR & mass spectrum analysis. Synthesized compounds shown biological activity against E. coli and B. Subtilis and anti-fungal activity against A. fumigates.

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