Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 4

Synthesis and Anti-microbial studies of (E)-4-Oxoalk-2-enoic acids

Abstract

(E)-4-Oxonon-2-enoic acid 1a is a fatty acid, isolated from the mycelium of Streptomyces olevaceus. Owing to its significant activity against various Gram-positive and Gram-negative strains and particularly Staphylococcus aureus ATCC 11632; it is an attractive target for structure-activity relationship. We report herein a straightforward synthesis of (E)-4-Oxonon-2- enoic acid 1a and its analogues in a single step using Wittig reaction. The antibacterial and antifungal activity assay of 1a and its analogues 1b-1g is presented.