Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2010 Vol: 2 Issue: 4

Synthesis and Anti-microbial studies of (E)-4-Oxoalk-2-enoic acids


(E)-4-Oxonon-2-enoic acid 1a is a fatty acid, isolated from the mycelium of Streptomyces olevaceus. Owing to its significant activity against various Gram-positive and Gram-negative strains and particularly Staphylococcus aureus ATCC 11632; it is an attractive target for structure-activity relationship. We report herein a straightforward synthesis of (E)-4-Oxonon-2- enoic acid 1a and its analogues in a single step using Wittig reaction. The antibacterial and antifungal activity assay of 1a and its analogues 1b-1g is presented.