Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2015 Vol: 7 Issue: 6

Synthesis and antimicrobial evaluation of some novel 1,3,4-oxadiazole


5-Nitro-1-benzofuran-2-carbohydrazide 2 was prepared by condensation of Ethyl-5-Nitro-1-bnzofuran-2- carboxylate 1 and hydrazine hydrate in Ethanol. The reaction of the 2 with various aromatic aldehydes to give 5-Nitro-N’-[aryl methylidene]-1-benzofuran-2-carbo hydrazide 3 which on cyclization with chloramine-T furnished 2-(5-Nitro-1-benzofuran-2-yl)-5-aryl-1,3,4-oxadiazole 4. The newly synthesized compounds have been characterized by IR, 1H NMR, MASS Spectra. The synthesized compounds were screened for antimicrobial activity. The purity of synthesized compound was confirmed by TLC.