Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2017 Vol: 9 Issue: 5

Synthesis and Antimicrobial Evaluation of Novel 4-substituted Phenyl-(2-oxo-2H-chromen-3-yl) Prop-2-en-1-ylidene Pyrimidine Derivatives


In this study a series of novel 4-substituted phenyl-(2-oxo-2H-chromen-3-yl) prop-2-en-1-ylidene pyrimidine derivatives have been synthesised by refluxing substituted 3-acetyl coumarin with barbituric/thiobarbituric acid and variety of substituted benzaldehyde in presences of 10 mol% CAN in ethanol with constant stirring for about 4-5 h. All the newly synthesised compounds were characterised by FTIR, 1H NMR, 13C NMR and mass spectrometry analysis and were screened for in vitro antimicrobial and antioxidant activity study.