Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2017 Vol: 9 Issue: 5

Synthesis and Antimicrobial Evaluation of Novel 4-substituted Phenyl-(2-oxo-2H-chromen-3-yl) Prop-2-en-1-ylidene Pyrimidine Derivatives

Abstract

In this study a series of novel 4-substituted phenyl-(2-oxo-2H-chromen-3-yl) prop-2-en-1-ylidene pyrimidine derivatives have been synthesised by refluxing substituted 3-acetyl coumarin with barbituric/thiobarbituric acid and variety of substituted benzaldehyde in presences of 10 mol% CAN in ethanol with constant stirring for about 4-5 h. All the newly synthesised compounds were characterised by FTIR, 1H NMR, 13C NMR and mass spectrometry analysis and were screened for in vitro antimicrobial and antioxidant activity study.