A series of 2-aminothiazoles derivatives have been synthesized and tested for in vitro antibacterial and antifungal activity on different microorganisms. Syntheses have been carried out following simple methodology in excellent isola ted yields. The structure and purity of the original compounds were confirmed by IR, NMR, and e lemental analysis. All compounds were tested for antibacterial and antifungal activity ag ainst Bacillus subtilus (+ve), E. coli (-ve), albicans (+ve) and Aspergillus niger (-ve) on conce ntration of 50 and 100μ g/ml by Disk- diffusion method. These preliminary results indicat e that some of compounds are exhibiting good activity.