A series of new mannich base derivatives 4-(furan-2-yl(2-(furan-2-yl methylene)hydrazinyl)methyl)morpholine(1-6) were synthesized and synthesized compounds (1- 6) were confirmed by IR, ¹H NMR, ¹³C NMR, Mass spectral, mass spectral fragmentation and elemental analysis. Synthesized compounds (1-6) were screened for antimicrobial activity. Structural activity relationship has been discussed in this paper.