Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2010 Vol: 2 Issue: 3

Synthesis and antimicrobial activity of novel spirotetrazines with thiazole and 4-thiazolidinone moiety

Abstract

The facile synthesis of 3-methyl-(III), 3,7-dimethy-6'(7'H)-oxo spiro[cyclohexane-1,3'(4'H)-[2H] thiazolo[3,2-b]-s-tetrazines](IV) and 3-methyl-6,7'-dihydro spiro[cyclohexan-1,3'(4'H)- [2H]thiazolo [3,2-b]-s-tetrazine](V)have been accomplished by reaction of 3-methyl-7,8,10,11- tetaaza spiro[5,5]undecane-9-thione (II) with chloroacetic acid, α-bromopropionic acid, 1,2- dibromoethane respectively. A reaction of II, obtained by reaction of 3-methylcyclohexanone (I) and thiocarbo hydrazide, with phenacyl bromide has been studied in varying conditions leading to the formation of 6'-aryl-3-methylspiro[cyclohexane-1,3'(4'H)-[2H]thiazolo[3,2-b]-s-tetrazine] (VII). The structures II-VII have been established by elemental analysis, IR, 1H NMR and mass spectral data. The sulphur containing compounds III-VII were screened for their antimicrobial activity.