Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2013 Vol: 5 Issue: 2

Synthesis and antimicrobial activity of 2-{4'-[(3"-aryl)-2"-propene-1"-N-(1,2,4- triazole) amino]}-6-[bis(2"'-chloro ethyl) amino]-4-methoxy-1,3,5-triazine


The titled compounds (5a-5k) have been synthesized by the condensation of 2-{4'-[(3"-aryl)-2"-Propene-1"-one]- Phenyl amino}-6-[Bis-2""-chloroethyl) amino]-4-methoxy-1,3,5-triazine with 4-amino -1,2,4 - triazole in alcohol. The biological activities of these compounds have been determined against various Gram +ve, Gram –ve bacteria and fungi. The constitutions of the products are supported by IR, 1 H NMR, Mass spectra and elemental analysis.